Scientists have identified the mechanism that allows breast cancer cells to lie dormant in other parts of the body, only to reemerge years later with lethal force, according to a study published on Tuesday.

In experiments with human cells and live mice, researchers showed that disabling the mechanism — with drugs or gene manipulation — crippled the cancer cells and inhibited their capacity to spread.

The discovery, reported in the journal Nature Communications, provides a promising target for the development of breast cancer therapies, the study said.

Some 90 percent of breast cancer deaths occur with metastasis, when the disease moves to other organs or parts of the body.

Scientists have struggled to understand how cancer cells manage to remain hidden — sometimes for decades — and what, exactly, triggers their reawakening.

“Our results suggest that breast cancer cells can survive, undetected, in patients for long periods by using a cellular process known as autophagy,” said co-author Kent Hunter, a researcher at the National Cancer Institute in Bethesda, Maryland, USA.

Autophagy occurs when any cell — healthy or cancerous — reshuffles internal components to survive in a stressful and nutrient-poor environment. This allows the cell to partially shut down, entering a state similar to hibernation.

The findings help explain why current treatments so often fail to root out breast cancer cells that remain after surgery and chemotherapy.

“Many of the traditional anti-cancer drugs are designed to target dividing cells,” said Hunter.

“Dormant cells, however, are not actively or frequently dividing, and are therefore thought to be resistant to these types of drugs.”

The fact that they are hiding elsewhere in the body also helps the cells escape localised treatments such as radiation.

In an experiment, researchers led by Hunter’s colleague Laura Vera-Ramirez injected dormant breast cancer cells into mice.

Half the animals were given a drug that inhibits autophagy, while the others received a placebo or “dummy” drug.

In a second experiment, they altered a gene that controls autophagy.

Both approaches “significantly” decreased survival of the cancer cells and limited their spread, the study concluded.

Without recourse to autophagy, the cancer cells accumulated toxic matter and damage to their mitochondria, the energy-producing units of cells.

The road to a viable treatment will be long, said Hunter. A clinical trial will have to be performed to determine whether the treatment would work in human patients.

It is also unknown whether the findings apply to other types of cancer, he added.

(AFP)

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    When talking when it comes to negative side effects, the answer is sure.
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    Although it could take time for muscle positive aspects to be visible in the mirror, it’s not unheard of for prohormone customers to gain upto 7-10 kilos in the first two weeks of their cycle.

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    Trenbolone Enanthate stacks properly with most,
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    So the subsequent question is how do we decide
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    Just do not forget that whenever you decide out of PCT, you place your body at a greater danger of side effects from the use of Tren Enanthate and different steroids.
    The commonest include headaches, upset abdomen and hot flashes.
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    Both Clomid and Nolvadex are good options for PCT but you only
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    it has the potential of permitting the individual to
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    kick-in time is between 2-four weeks of the cycle.
    Many ask the question then is it extra helpful to run a shorter cycle of Testosterone Propionate.

    The length and kick-in period of Testosterone Cypionate cycles is essential to know.
    Testosterone Cypionate holds a half-lifetime of 12 days, which requires an prolonged Testosterone Cypionate cycle length of roughly 10 – 12 weeks.

    Because of the longer period of time required for optimum peak, stable blood
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    GH might be the only most essential drug to take care of muscle mass
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    Tren is a progestin so can be extremely inhibitive of
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    Even small doses can lead to a substantial amount of muscle achieve or fat loss.
    Both newbies at a very low dosage can use Trenbolone, but this is
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    Its use is just for the advanced and serious about constructing muscle.

    While GH isn’t identified to be nice for anabolic results, it is rather effective for anti-catabolism.
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